SEVERE CHRONIC PERIODONTITIS AND C-REACTIVE PROTEIN LEVELS
DOI :
https://doi.org/10.13102/rscdauefs.v6i2.1168Mots-clés :
periodontitis, C-reactive protein, inflammatory responseRésumé
This study aims to analyze the relationship between chronic periodontitis and C-reactive protein (CRP), taking certain associated factors into consideration. A cross-sectional study was conducted on a sample of 75 adults of both sexes. After the participants had been interviewed, they underwent physical and dental examinations and blood collection. CRP levels were evaluated by means of nephelometry. A periodontal clinical examination was conducted by trained examiners and the diagnosis of chronic periodontitis was established when at least 30% of the individual’s teeth presented clinical attachment loss ≥ 5 mm. The analysis procedures consisted of descriptive analysis and linear regression. The results showed that there was no statistically significant difference in CRP levels between the groups with and without periodontitis. The median CRP level in the group with periodontitis was 2.3 mg/l (25-75% interquartile range, IQR = 0.74-5.4) and in the group without periodontitis, 1.8 mg/l (25-75% IQR = 0.79-4.54) (p = 0.417). Log CRP was significantly correlated only with the individual’s body mass index (BMI). The main findings from this study indicate that there is no association between severe chronic periodontitis and CRP, and factors like BMI need to be analyzed carefully in studies on this topic.
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Scannapieco FA. Periodontal inflammation: from gingivitis to systemic disease? Compend Contin Educ Dent. 2004;25:16-25.
Golub LM, Payne JB, Reinhardt RA, Nieman G. Can systemic diseases co-induce (not just exacerbate) periodontitis? A hypothetical "two-hit" model. Dent Res. 2006, 85:102-105.
Agueda A, Echeverría A, Manau C. Association between periodontitis in pregnancy and preterm or low birth weight: Review of the literature. Med Oral Patol Oral Cir Bucal. 2008;13:E609-615.
Azarpazhooh A, Leake JL. Systematic review of the association between respiratory diseases and oral health. J Periodontol. 2006;77:1465-1482.
Scannapieco FA, Dasanayake AP, Chhun N. Does periodontal therapy reduce the risk for systemic diseases? Dent Clin North Am. 2010;54:163-181.
Fukui, N. et al., Periodontal Status and Metabolic Syndrome in Middle-Aged Japanese. Journal of Periodontology, v. 83, p. 1363-1371, 2012.
Lima JCC, Silva MAS, Lima DS. C-reactive protein as a risk marker in cardiovascular disease(In Portuguese). Atheros 2002;13:20-22.
Goldie MP.C-reactive protein, cardiovascular disease, and periodontal disease. Int J Dent Hyg. 2004; 2:139-141.
Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499-511.
American Heart Association. Inflammation, Heart Disease and Stroke: The Role of C Reactive Protein. Available at: http:// www.americanheart.org/presenter/jhtml? identifier=4648. Accessed September-25, 2010.
Alley DE, Seeman TE, Ki Kim J, Karlamangla A, Hu P, Crimmins EM.
Socioeconomic status and C-reactive protein levels in the US population: NHANES IV. Brain Behav Immun 2006;20:498-504.
Nazmi A, Victora CG. Socioeconomic and racial/ethnic of C- reactive protein levels: a systematic review of population-based studies. BMC Public Health 2007; 7: 212-256.
Petersen KL, Marsland AL, Flory J, Votruba-Drzal E, Muldoon MF, Manuck SB. Community socioeconomic status is associated with circulating interleukin-6 and C-reactive protein. Psychosom Med. 2008;70:646-652.
Saito T, Murakami M, Shimazaki Y, Oobayashi K, Matsumoto S, Koga T. Association between alveolar bone loss and elevated serum C-reactive protein in Japanese men. J Periodontol. 2003;74:1741-1746.
Braga FSFF, Fischer RG, Figueredo CMS. C-reactive protein in the diagnosis of periodontal lesions with systemic reflexes. (In Portuguese) RBO 2004; 61: 28-31.
D’aiuto F, Ready, D, Tonetti MS. Periodontal disease and C-reactive protein associated cardiovascular risk. J Periodontol Res 2004; 39; 236–241.
Czerniuk MR, Górska R, Filipiak KJ, Opolski G.C-reactive protein in patients with coexistent periodontal disease and acute coronary syndromes. J Clin Periodontol. 2006;33:415-220.
Bezerra CFR, Amaral BA, Camelo FP , Aquino ARL, Seabra EG, Carreiro AFP. The c-reactive protein role in the relationship between periodontal and cardiovascular diseases. R. Periodontia, v. 18, p 18(1):7-13, 2008.
Gomes-Filho IS, Freitas Coelho JM, Seixas da Cruz S, Passos JS, Teixeira de Freitas CO, Aragão Farias NS, et al. Chronic Periodontitis and C-reactive Protein Levels. J Periodontol. 2010.
Reis HFC, Ladeia AMT, Passos EC, Santos FGO, Wasconcellos LTde, Correia LCL et al . Prevalence and variables associated with physical inactivity in individuals with high and low socioeconomic status. Arq. Bras. Cardiol 2009; 92: 203-208.
Hass NA, Rosing CK, Oppermann RV, Albandar JM, Susin C. Association among menopause, hormone replacement therapy, and periodontal attachment loss in southern brazilian women. J Periodontol 2009;80( 9):1380-1387.
Azorrilla EP, Luborsky L, McKay JR, Rosenthal R, Houldin A, Tax A, et al. The relationship of depression and stressors to immunological assays: a meta analytic review. Brain Behav Immun. 2001;15:199-226.
Callahan L, Pincus T. Prognostic markers of activity and damage in rheumatoid arthritis: why clinical trials and inception cohort studies indicate more favourable outcomes than studies of patients with established disease. Br J Rheumatol 1995;34:196-9.
Katz MH. Multivariate Analysis: a practical guide for clinicians. Cambridge: Cambridge University Press, 1999.
Cullinan MP, Ford PJ, Seymour G J. Periodontal disease and systemic health: current status. Aust Dent J. 2009;54:S62-69.
