Leucine-aminopeptidase A (LAP-A) Encoding Gene in Apoidea: from Genomic Identification to Functional Insights Based on Gene Expression


  • Luana Bataglia Universidade de São Paulo (USP)
  • Isabel Cristina Godoy Universidade Federal de São Carlos (UFSCar)
  • Marco Antonio Del Lama Universidade Federal de São Carlos (UFSCar)
  • Francis Morais Franco Nunes Universidade Federal de São Carlos (UFSCar)




Lap-A, bee, gene expression, aminopeptidase, PCR


Aminopeptidases are enzymes that cleave the N-terminal region of proteins and show structural conservation in prokaryotes and eukaryotes. We aimed to identify leucine-aminopeptidase A (LAP-A) orthologs in the genome of bee species with diff erent levels of social organization, and to explore the putative roles of this enzyme based on gene expression data. We identified a single gene for LAP-A on chromosome 15 of Apis mellifera L. and predicted orthologs in genomes of 11 bee species. We found evidence of LAP-A expression in more than 50 bee species. In honeybee and other bees, LAP-A transcripts were expressed in diverse tissues, including: brains, fat bodies, ovaries, testicles, integuments, and glands, on diff erent developmental stages that spanned from embryogenesis to adult life. Our fi ndings on the transcriptional activity of LAP-A are consistent with previously published data on enzymatic activity of LAP-A in bees throughout the development in different tissues and in both sexes. The presence of LAP-A gene in the Apoidea genomes and its ubiquitous expression support housekeeping roles of this enzyme and broad-spectrum functions in bees, independente of their life styles.


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How to Cite

Bataglia, L., Godoy, I. C., Del Lama, M. A., & Nunes, F. M. F. (2018). Leucine-aminopeptidase A (LAP-A) Encoding Gene in Apoidea: from Genomic Identification to Functional Insights Based on Gene Expression. Sociobiology, 65(4), 654–661. https://doi.org/10.13102/sociobiology.v65i4.3475



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